Bisphenol A Genomics Data Portal BPA structure static BPA structure animated
Bisphenol A (BPA)
SMILES: CC(C)(c1ccc(O)cc1)c1ccc(O)cc1
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This is a web-portal for accessing our database of genomics datasets related to health effects of BPA exposure. Genomics data types in this portal range from simple gene expression datasets to comparative genomics hybridization and epigenomics datasets. Please see the slides for the objectives of this portal and the example of how to analyze the data in the portal.

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24 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Arrays. Bisphenol A effect on nonmalignant breast epithelial cell aspirates from breast cancer patients. Analysis of random periareolar fine-needle aspirates collected from unafflicted, contralateral breast tissue of breast cancer patients and treated with bisphenol A (BPA).Results provide insight into early molecular events induced by BPA in susceptible breast tissue Dairkee SH, Seok J, Champion S, Sayeed A et al. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res 2008 Apr 1;68(7):2076-80.
36 Agilent-014868 Whole Mouse Genome Microarray 4x44K.Uterine gene profiles fromOvariectomized WT, KIKO (DNA-binding deficient ERα) or αERKO female mice were injected (ip) with saline (vehicle), estradiol (E2; 250 ng), bisphenol A (BPA; 750 µg) or 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE; 750 µg) and uteri were collected after 2 or 24 hours. Uterine profiles were compared and indicated the early (2 hour) responses to E2 were highly correlated to the BPA and HPTE profiles. Note: Sample values are log2 of ratio of treatment/control. Hewitt SC et al.Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol.Mol Endocrinol. 2009 Dec;23(12):2111-6. Epub 2009 Oct 7.
20 Agilent-014868 Whole Mouse Genome Microarray 4x44K. Potential mechanisms of endocrine disruptors as revealed by uterine gene profile. Females were ovariectomized and injected with sesame oil, estradiol in sesame oil, BPA in sesame oil or HPTE in sesame oil. Uterine tissue was collected after 2 or 24 hours. RNA was analyzed by microarray compare ealry and late responses to a potent and a weak estrogen agaonist. NA