How perturbagen connectivity analysis is performed in iLINCS

The connectivity between a query signature and a “perturbagen” is established using the enrichment analysis of individual connectivity scores between the query signature and set of all L1000 signatures of the perturbagen (for all cell lines, time points and concentrations). The analysis establishes whether the connectivity scores as a set are “unusually” high based on the Random Set analysis.

Last updated on 2nd Jun 2020