ENCODE transcription factor binding signatures
Transcription factor (TF) binding signatures constructed using ENCODE ChiP-seq data. Each signature consists of genome scale (i.e. for each gene) scores and probabilities of regulation by the given TF in the specific context (cell line and treatment). These signatures were developed using our in-house TREG methodology.
True REGulation (TREG) method integrates Transcription factor (TF) information from all binding 'peaks' with 2Mb window around gene's transcription start site (TSS) and provides gene-level binding scores and probabilities of regulatory interaction. Subsequently, binding scores and regulatory probabilities are integrated with gene expression data to assess the likelihood of True REGulatory TF-gene interactions.
For more information, please refer to https://dx.doi.org/10.1371%2Fjournal.pcbi.1003198